The following is a first pass at a list of mutations using 5th Edition D&D rules for a post-apocalypse setting. Most of the mutations are beneficial, some are detrimental and a few are just benign. Many are combed from monster and class abilities already present in the PHB and MM, others are inspired by other sources and a few I made up myself.
Please note, I’ve made no attempt to balance these mutations; some are vastly superior to others. It’s not really intended that you slap these mutations onto standard 5th Edition characters, though you can certainly do so if you wish. I may (or may not) eventually roll this out to a more fleshed-out PA setting…well see.
Here you go: 5th Edition Mutations